Betadine® antiseptics are among the most effective antiseptics available, inactivating infecting organisms including bacteria and fungi. Povidone-iodine solutions are a golden-brown colour because of the iodine content. This colour shows the area that has been treated and also denotes the activity of the product. As the iodine is depleted from the solution, the colour fades. When the colour fades to a light yellow, Betadine® should be reapplied. In most cases Betadine® antiseptics are non-irritating and non-stinging to the skin. They do not permanently stain the skin or natural fabrics and the treated areas may be bandaged, taped or otherwise covered.